[HTML][HTML] Physiological systems in promoting frailty

LR Perazza, HM Brown-Borg… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Insulin and aging–a disappointing relationship

H Kolb, K Kempf, S Martin - Frontiers in Endocrinology, 2023 - frontiersin.org
Experimental studies in animal models of aging such as nematodes, fruit flies or mice have
observed that decreased levels of insulin or insulin signaling promotes longevity. In humans …

Changes of Signaling Pathways in Hypothalamic Neurons with Aging

PM Masliukov - Current Issues in Molecular Biology, 2023 - mdpi.com
The hypothalamus is an important regulator of autonomic and endocrine functions also
involved in aging regulation. The aging process in the hypothalamus is accompanied by …

Nutrient-response pathways in healthspan and lifespan regulation

A Dabrowska, J Kumar, C Rallis - Cells, 2022 - mdpi.com
Cellular, small invertebrate and vertebrate models are a driving force in biogerontology
studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila …

Juvenile hormone suppresses the FoxO-takeout axis to shorten longevity in male silkworm

Z Li, J Song, G Jiang, Y Shang, Y Jiang, J Zhang… - Pesticide Biochemistry …, 2023 - Elsevier
Juvenile hormone (JH) plays a crucial endocrine regulatory role in insect metamorphosis,
reproduction, and longevity in multiple organisms, such as flies, honeybees, and migratory …

[HTML][HTML] Promotion of longitudinal bone growth by the intake of oat and green onion root water extracts in weaning rats through stimulating growth hormone secretion …

X Wu, T Zhang, HJ Yang, Y Yue, MJ Kim, C Li… - Journal of Functional …, 2023 - Elsevier
We determined whether oral oat and green onion water extracts (GOO) supplementation
could stimulate longitudinal bone growth in weaning rats. Fistuloside A, B, and C in the …

Age-Related Dynamics of Insulin Signaling in Neurons of the Rat Hypothalamic Tuberal Nuclei

PA Anfimova, VV Porseva, LG Pankrasheva… - Journal of Evolutionary …, 2024 - Springer
The hypothalamus is a regulatory center that controls homeostasis, reproduction, circadian
rhythms, and the endocrine system. It is also involved in the regulation of aging. The …

[HTML][HTML] Responses to Many Anti-Aging Interventions Are Sexually Dimorphic

A Bartke, E Hascup, K Hascup - The World Journal of Men's Health, 2024 - ncbi.nlm.nih.gov
There is increasing appreciation that sex differences are not limited to reproductive organs
or traits related to reproduction and that sex is an important biological variable in most …