Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …

Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Supersaturating drug delivery system (SDDS) is a promising approach to enhance the
solubility of hydrophobic functional components. However, SDDS is thermodynamically …

Solid dispersions (SDs) have emerged as a promising strategy to enhance the solubility and
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …

Co-amorphous systems are amorphous formulations stabilized by the miscible dispersion of
small molecules. This study aimed to design a stable co-amorphous system for the co …

Ellagic acid is one of the most studied polyphenolic compounds due to its numerous
promising therapeutic properties. However, this therapeutic potential remains difficult to …

This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …

The microphases and miscibility in binary curcumin (Cur) solid dispersions (SDs) with
amorphous polyvinylpyrrolidone K30 (PVP K30) and semi-crystalline poloxamer (P407) and …

The fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make
the most of the solubility advantage of the amorphous form of a drug. However, the drug …

The preparation of solid dispersions by mixing insoluble drugs with polymers is the main
way to improve the aqueous solubility of drugs. The introduction of organic small molecule …