Use of in vivo animal models to assess drug–drug interactions
T Prueksaritanont - Enzyme-and Transporter-Based Drug-Drug …, 2010 - Springer
In this chapter, theoretical basis and specific examples are presented to illustrate the utility of
the animal models in assessing and understanding the underlying mechanisms of DDIs. In …
the animal models in assessing and understanding the underlying mechanisms of DDIs. In …
Drug disposition and drug–drug interactions: importance of first-pass metabolism in gut and liver
CK Yeung, P Zhao, DD Shen, KE Thummel - Enzyme-and Transporter …, 2010 - Springer
Drugs with high intestinal and hepatic extraction that undergo biotransformation are often
involved in significant metabolic drug–drug interactions when co-administered with enzyme …
involved in significant metabolic drug–drug interactions when co-administered with enzyme …