Celecoxib for the treatment of musculoskeletal arthritis

M Krasselt, C Baerwald - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
ABSTRACT Introduction: The cyclooxygenase (COX)-2 inhibitor celecoxib is an approved
compound for rheumatoid (RA) and osteoarthritis (OA), combining both anti-inflammatory …

[图书][B] Deadly medicines and organised crime: how big pharma has corrupted healthcare

P Gotzsche - 2019 - taylorfrancis.com
PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …

Cardiovascular complications of non-steroidal anti-inflammatory drugs

E Fosslien - Annals of Clinical & Laboratory Science, 2005 - Assoc Clin Scientists
Coxibs, such as rofecoxib, celecoxib, and valdecoxib, selectively inhibit cyclooxygenase
(COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non …

[HTML][HTML] Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment

P Marmon, SF Owen, L Margiotta-Casaluci - Environment international, 2021 - Elsevier
The presence of non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment
has raised concern that chronic exposure to these compounds may cause adverse effects in …

Anti‐inflammatory activity of pyridazinones: A review

MSA Hassan, EM Ahmed, AA El‐Malah… - Archiv der …, 2022 - Wiley Online Library
The pyridazinone core has emerged as a leading structure for fighting inflammation, with low
ulcerogenic effects. Moreover, easy functionalization of various ring positions of the …

Molecular hybrid design, synthesis and biological evaluation of N-phenyl sulfonamide linked N-acyl hydrazone derivatives functioning as COX-2 inhibitors: new anti …

V Gorantla, R Gundla, SS Jadav, SR Anugu… - New Journal of …, 2017 - pubs.rsc.org
Herein, we report the design, synthesis and biological evaluation of the anti-inflammatory
activities of N-phenyl sulfonamide linked N-acylhydrazones (NPS–NAH), using the …

[HTML][HTML] The safety of celecoxib as an acute treatment for migraine: A narrative review

J Ailani, SJ Nahas, DI Friedman, T Kunkel - Pain and Therapy, 2023 - Springer
Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the first-line choice
for the acute treatment of migraine attacks for decades; however, the safety of a particular …

In vivo evaluation of [11C] TMI, a COX-2 selective PET tracer, in baboons

JSD Kumar, F Zanderigo, J Prabhakaran… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract Overexpression of Cyclooxygenase-2 (COX-2) enzyme is associated with the
pathogenesis of inflammation, cancers, stroke, arthritis, and neurological disorders. Because …

[HTML][HTML] Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications

M Alomar, S Palaian, MM Al-Tabakha - F1000Research, 2019 - ncbi.nlm.nih.gov
Considering that marketed drugs are not free from side effects, many countries have initiated
pharmacovigilance programs. These initiatives have provided countries with methods of …

[图书][B] Tödliche Medizin und organisierte Kriminalität: wie die Pharmaindustrie unser Gesundheitswesen korrumpiert

PC Gøtzsche - 2014 - books.google.com
Ein Pharmakonzern wurde durch den Verkauf von Heroin groß. Ein anderer steht im
Verdacht, mit falschen Behauptungen über ein Arthritis-Medikament den Tod von …