Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume

M Desai, A Kundu, M Hageman, H Lou, D Boisvert - MAbs, 2023 - Taylor & Francis
Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of
these treatments are administered intravenously by trained healthcare professionals, a …

Intradermal delivery of naked mRNA vaccines via iontophoresis

M Hasan, A Khatun, K Kogure - Pharmaceutics, 2023 - mdpi.com
Messenger RNA (mRNA) vaccines against infectious diseases and for anticancer
immunotherapy have garnered considerable attention. Currently, mRNA vaccines …

[HTML][HTML] Hollow silicon microneedles, fabricated using combined wet and dry etching techniques, for transdermal delivery and diagnostics

C O'Mahony, R Sebastian, F Tjulkins, D Whelan… - International Journal of …, 2023 - Elsevier
Microneedle-based technologies are the subject of intense research and commercial
interest for applications in transdermal delivery and diagnostics, primarily because of their …

[HTML][HTML] Best practice recommendations for the management of anxiety during the pegvaliase journey

KJ Bjoraker, C Eggerding, E Ellenberg… - Molecular genetics and …, 2024 - Elsevier
Background Pegvaliase, an enzyme substitution therapy, is a treatment option for
phenylketonuria (PKU). Due to the neuropathophysiology and disease burden of PKU …

A novel scenario in the therapeutic management of anemia of chronic kidney disease: placement and use of roxadustat

F Locatelli, M Ravera, C Esposito, G Grandaliano… - Journal of …, 2024 - Springer
Anemia is a frequent and early chronic kidney disease (CKD) complication. Its management
is currently based on oral or intravenous iron supplements, erythropoiesis-stimulating …

Needle phobia among adult jordanians: General awareness, prevalence; and exploring microneedles as a promising solution

S Abdelghany, S Al-Muhaissen, YA Thaher, M Melhem… - Plos one, 2023 - journals.plos.org
Needle phobia remains a major drawback of conventional injectable medications, leading to
avoidance and low adherence among a reasonable portion of patients. Despite this, there is …

MEDIC: Development and validation of a new instrument to assess emotional reactivity to medical stimuli in a representative community sample of adults

K Phillips, BL Callaghan, A Webb, J Kan, CY Ooi… - Journal of Psychiatric …, 2024 - Elsevier
To support investigation of the etiology and psychophysiology of medical traumatic stress,
we developed a standardized set of emotionally-salient medical images, called the 'MEDical …

A Bioinspired and Cost‐Effective Device for Minimally Invasive Blood Sampling

N Zoratto, D Klein‐Cerrejon, D Gao… - Advanced …, 2024 - Wiley Online Library
Conventional venipuncture is invasive and challenging in low and middle‐income countries.
Conversely, point‐of‐care devices paired with fingersticks, although less invasive, suffer …

Prevalence, factors associated and management of needle phobia among the general population in Saudi Arabia and Egypt

H Alwafi, AY Naser, NA Alsaleh, JK Asiri… - BMC psychiatry, 2024 - Springer
Objective This study aims to assess the prevalence of needle phobia among Saudi and
Egyptian adult populations. In addition, underlying causes and strategies that can be utilized …

Evaluating unmet needs in large-volume subcutaneous drug delivery: US payer perspectives on a novel, large-volume on-body delivery system

M Desai, J Kenney, E Pezalla - Current Medical Research and …, 2024 - Taylor & Francis
Objective Existing healthcare systems face finite resource allocation and budgetary
constraints, resulting in a substantial need for innovative solutions to enhance service …