A narrative review of ERBB2 in non-small cell lung carcinoma

M Sharma, A Dewan, H Diwan… - Cancer Research …, 2022 - journals.lww.com
The plethora of biomarkers and the availability of targeted treatment have revolutionized the
therapeutic profile of non-small cell lung cancer (NSCLC). Erythroblastic oncogene B …

[HTML][HTML] Phase II study of afatinib plus pembrolizumab in patients with squamous cell carcinoma of the lung following progression during or after first-line …

B Levy, F Barlesi, L Paz-Ares, J Bennouna, M Erman… - Lung Cancer, 2022 - Elsevier
Introduction Afatinib and pembrolizumab have separately shown survival benefit in patients
with squamous cell carcinoma (SqCC) of the lung, and there is biological rationale for …

[HTML][HTML] Squamous cell lung cancer: genomic evolution and personalized therapy

AF Cardona, L Ricaurte… - salud pública de …, 2020 - SciELO Public Health
Objective: To review the state-of-the-art in relation to the current information on squamous
cell lung cancer (SCLC). We describe the genetic anomalies reported, their effect, and finally …

[HTML][HTML] 晚期肺鳞癌治疗进展

高鸣, 周清 - Chinese Journal of Lung Cancer, 2020 - ncbi.nlm.nih.gov
肺癌是世界及中国发病率和死亡率第一的恶性肿瘤, 肺鳞癌因其独特的临床表现、
病理表现及基因突变特征, 在诊治中与肺腺癌的区别显著, 在临床研究中也作为单独的类型 …

In vitro validation study of HER2 and HER4 mutations identified in an ad hoc secondary analysis of the LUX-Lung 8 randomized clinical trial

A Hamada, K Suda, T Koga, T Fujino, M Nishino… - Lung Cancer, 2021 - Elsevier
Abstract Objectives The LUX-Lung 8 randomized trial (LL8) demonstrated a prolonged
progression-free survival (PFS) in patients with metastatic squamous cell carcinoma (SCC) …

[PDF][PDF] 肺鳞状细胞癌靶向治疗研究进展

刘传, 李琦 - 肿瘤, 2024 - tumorsci.org
肺鳞状细胞癌是肺癌的主要组织学类型之一. 与肺腺癌不同, 肺鳞状细胞癌患者从靶向治疗中的
获益有限. 虽然免疫治疗显著改善了肺鳞状细胞癌患者的预后, 但是相对较低的有效率和相关 …

Actualización de las recomendaciones para la determinación de biomarcadores predictivos en el carcinoma de pulmón de célula no pequeña avanzado. Consenso …

F López-Ríos, L Paz-Ares, J Sanz, D Isla… - Revista Española de …, 2020 - Elsevier
En el año 2011 se inició un proyecto conjunto entre la Sociedad Española de Oncología
Médica (SEOM) y la Sociedad Española de Anatomía Patológica (SEAP) para establecer …

The role of miRNA-571 and miRNA-559 in lung cancer by affecting the expression of genes associated with the ErbB signaling pathway

SA Jasim, HA Omear, AH Al-Marzoqi - Gene Reports, 2022 - Elsevier
Background Abnormal expression and activity of the ErbB pathway has been revealed in
many cancers, such as lung cancer. The inappropriate activity of EGFR, MAPK1 and PAK2 …

Pharmacokinetics of Afatinib after Intravenous and Oral Administrations in Rats Using Validated UPLC MS/MS Assay

AS Almurshedi, MA Radwan… - Journal of …, 2024 - academic.oup.com
Afatinib is designated as the first-line management therapy for patients with advanced non-
small cell lung cancer, and metastatic head and neck cancer. LC coupled to MS/MS can be …

PD-L1 Protein Expression and Gene Amplification Correlate with the Clinicopathological Characteristics and Prognosis of Lung Squamous Cell Carcinoma

Z Chen, N Zhao, Q Wang, Y Xi, X Tian… - Cancer Management …, 2021 - Taylor & Francis
Purpose To investigate PD-L1 protein expression and gene amplification in lung squamous
cell carcinoma (LUSC) and analyse their correlation with the clinicopathological …