Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of …
S Baghel, H Cathcart, NJ O'Reilly - Journal of pharmaceutical sciences, 2016 - Elsevier
Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Recent advances in co-amorphous drug formulations
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs
Over 40% of active pharmaceutical ingredients (API) in development pipelines are poorly
water-soluble drugs which limit formulation approaches, clinical application and …
water-soluble drugs which limit formulation approaches, clinical application and …
Application of differential scanning calorimetry (DSC) and modulated differential scanning calorimetry (MDSC) in food and drug industries
Phase transition issues in the field of foods and drugs have significantly influenced these
industries and consequently attracted the attention of scientists and engineers. The study of …
industries and consequently attracted the attention of scientists and engineers. The study of …
Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate
G Van den Mooter - Drug Discovery Today: Technologies, 2012 - Elsevier
The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …
An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused …
M Alhijjaj, P Belton, S Qi - European Journal of Pharmaceutics and …, 2016 - Elsevier
FDM 3D printing has been recently attracted increasing research efforts towards the
production of personalized solid oral formulations. However, commercially available FDM …
production of personalized solid oral formulations. However, commercially available FDM …