Alzheimer's disease (AD) is a major cause of dementia and exhibits a complex and diverse
pathogenesis with limited clinical treatment options, especially for patients in advanced …

Alzheimer's disease (AD) is a leading cause of cognitive impairment worldwide. Overweight
and obesity are strongly associated with comorbidities, such as hypertension, diabetes, and …

Introduction Although the association between Alzheimer's disease (AD) and constipation is
controversial, its causality and underlying mechanisms remain unknown. Objectives To …

Obesity represents a significant public health concern and is linked to various comorbidities
and cognitive impairments. Previous research indicates that elevated body mass index (BMI) …

Drug repositioning greatly reduces drug development costs and time by discovering new
indications for existing drugs. With the development of technology and large-scale biological …

Objectives The cross-sectional association between late-life obesity and dementia is often
explained by the obesity paradox. We assessed the potential differential associations of …

Aims Recent evidence indicated the biological basis of complement 1q (C1q)/tumor necrosis
factor (TNF)‐related protein (CTRP) 3, 4, and 14 for affecting brain structure and cognitive …

The hypothalamus is the region of the brain that integrates the neuroendocrine system and
whole‐body metabolism. Patients with Alzheimer's disease (AD) have been reported to …

Abstract Aims White matter lesions (WMLs) are involved in the pathological processes
leading to cognitive decline and dementia. We examined the mechanisms underlying the …