Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues
and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin …

When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease
from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein …

Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …

Sepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units.
However, the molecular mechanisms underlying septic cardiomyopathy remain elusive …

Cardiovascular diseases are the most common cause of death in the world. One of the major
causes of cardiac death is excessive apoptosis. However, multiple pathways through …

Obesity is a worldwide health problem due to the imbalance of energy intake and energy
expenditure. Irisin, a newly identified exercise‐responsive myokine, which is produced by …

Obesity, which is driven by inflammation and oxidative stress, is a risk factor for
cardiovascular disease. Semaglutide, a glucagon-like peptide-1 receptor agonist, is an …

Irisin is an exercise-induced myokine known to induce adipocyte browning through
induction of uncoupling protein 1. Recent studies have reported that irisin is also an …