Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
Reassessing human adipose tissue
AM Cypess - New England Journal of Medicine, 2022 - Mass Medical Soc
Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …
then return to baseline. This review discusses the functional roles of human white and brown …
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
C Li, K Yu, N Shyh‐Chang, Z Jiang… - Journal of cachexia …, 2022 - Wiley Online Library
Age‐associated obesity and muscle atrophy (sarcopenia) are intimately connected and are
reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing …
reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing …
The role of hepatokines in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …
but it is also an important cause of insulin resistance and major non-communicable diseases …
Associations between body-mass index and COVID-19 severity in 6· 9 million people in England: a prospective, community-based, cohort study
Background Obesity is a major risk factor for adverse outcomes after infection with SARS-
CoV-2. We aimed to examine this association, including interactions with demographic and …
CoV-2. We aimed to examine this association, including interactions with demographic and …
NLRP3 inflammasome in cancer and metabolic diseases
BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
Macrophage function in adipose tissue homeostasis and metabolic inflammation
Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
NAFLD and cardiovascular diseases: a clinical review
P Kasper, A Martin, S Lang, F Kuetting… - Clinical research in …, 2021 - Springer
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in
Western countries and affects approximately 25% of the adult population. Since NAFLD is …
Western countries and affects approximately 25% of the adult population. Since NAFLD is …
Association of insulin resistance and elevated androgen levels with polycystic ovarian syndrome (PCOS): a review of literature
Y Xu, J Qiao - Journal of healthcare engineering, 2022 - Wiley Online Library
The polycystic ovary syndrome (PCOS) is the disease featured by elevated levels of
androgens, ovulatory dysfunction, and morphological abnormalities. At reproductive stage of …
androgens, ovulatory dysfunction, and morphological abnormalities. At reproductive stage of …