Asthma is a globally significant non-communicable disease with major public health
consequences for both children and adults, including high morbidity, and mortality in severe …

Overall, asthma mortality rates have declined dramatically in the last 30 years, due to
improved diagnosis and to better treatment, particularly in the 1990s following the more …

Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

There is increasing interest in the origins of chronic obstructive pulmonary disease (COPD),
as it is envisaged that preventive efforts and treatment can modify its clinical course. The …

Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Genetic factors, atopy, and early respiratory …

Rationale: The burden of chronic obstructive pulmonary disease (COPD) is increasing, yet
there are limited data on early life risk factors. Objectives: To investigate the role of …

Rationale: Cohort studies suggest that airflow obstruction is established early in life,
manifests as childhood asthma and wheezy bronchitis, and continues into early adulthood …

COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …

Asthma-COPD overlap (ACO) is a heterogeneous condition that describes patients who
show persistent airflow limitation with clinical features that support both asthma and COPD …

Asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is
characterized by persistent airflow limitation with several features usually associated with …