Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of
patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD) …

A fibromialgia (FM) é uma síndrome clínica comumente observada na prática médica diária
e possui etiopatogenia ainda obscura. Caracterizada por quadro de dor …

BACKGROUND: Recent neurophysiological evidence attests to the validity of fibromyalgia
(FM), a chronic pain condition that affects> 2% of the population. OBJECTIVES: To present …

Purpose Adherence to aromatase inhibitor (AI) therapy for early-stage breast cancer is
limited by AI-associated musculoskeletal symptoms (AIMSS). Duloxetine is US Food and …

The heterogeneity of the clinical presentation and the pathophysiologic mechanisms
associated with fibromyalgia (FM), and the modest results on average for any therapy, call …

The generalized hypersensitivity associated with fibromyalgia syndrome (FMS) may in part
be driven by peripheral nociceptive sources. The aim of the study was to investigate whether …

Chronic pain exerts a tremendous burden on individuals and societies. If one views chronic
pain as a single disease entity, then it is the most common and costly medical condition. At …

The objective of this paper is to better understand the relationship of pain and mood in
patients with fibromyalgia and comorbid major depressive disorder (MDD). Pooled data from …

Background Impaired pain inhibitory and enhanced pain facilitatory mechanisms are
repeatedly reported in patients with central sensitization pain. However, the exact effects of …

OBJECTIVES: To provide an update on advances in pain research and practical guidelines
for pain management in the rheumatic diseases. METHODS: A selected literature review …