We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Many genetic and environmental factors contribute to development of cancer, but DNA
methylation may provide a link between these influences. Genome stability and normal gene …

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …

Both epidemiologic and experimental animal studies demonstrate that chronic psychological
stress exerts adverse effects on the initiation and/or progression of many diseases …

We investigated the role of the breast cancer resistance protein (BCRP/ABCG2) in drug
resistance in multiple myeloma (MM). Human MM cell lines, and MM patient plasma cells …

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …

Acquisition of drug resistance is one of the main obstacles encountered in cancer
chemotherapy. Overexpression of multi-drug resistance 1 (MDR1) gene and its protein …

There has been an increasing appreciation of the role of drug transporters in the
pharmacokinetic and pharmacodynamic profiles of certain drugs. Among various drug …

Increased expression of ABC-family of transporters is associated with chemotherapy failure.
Although the drug transporters ABCG2, ABCB1 and ABCC1 have been majorly implicated in …

The multidrug resistance (MDR) phenotype is the major cause of failure of cancer
chemotherapy. This phenotype is mainly due to the overexpression of the human MDR1 …