Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These
organelles have a high plasticity and are involved in dynamic processes such as …

Abstract Background Type 2 diabetes (T2DM) and Parkinson's disease (PD) are prevalent
diseases that affect an aging population. Previous systematic reviews and meta‐analyses …

Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-
adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This …

Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin
resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels …

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS …

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds
endogenous antioxidant capacity. In this paper, we review the specific role of several …

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …