The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Abstract Store-Operated Ca 2+ entry (SOCE) is recognized as a key mechanism in muscle
physiology necessary to refill intracellular Ca 2+ stores during sustained muscle activity. For …

Intracellular Ca2+ ions represent a signaling mediator that plays a critical role in regulating
different muscular cellular processes. Ca2+ homeostasis preservation is essential for …

Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) form a clinical
continuum associating progressive muscle weakness with additional multi-systemic …

Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) are clinically
overlapping disorders characterized by childhood-onset muscle weakness and a variable …

Two likely causative mutations in the RYR1 gene were identified in two patients with
myopathy with tubular aggregates, but no evidence of cores or core‐like pathology on …

Aims Limb‐girdle congenital myasthenic syndrome (LG‐CMS) is a genetically
heterogeneous disorder characterised by muscle weakness and fatigability. The LG‐CMS …

In skeletal muscle, Ca2+ necessary for muscle contraction is stored and released from the
sarcoplasmic reticulum (SR), a specialized form of endoplasmic reticulum through the …

Abstract Purpose Metabolic syndrome (MetS) became a tremendous public health burden in
the last decades. Store-operated calcium entry (SOCE) is a unique mechanism that causes …