Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and …

Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

Abstract The International League Against Epilepsy (ILAE) defined a seizure as “a transient
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …

Preclinical research has facilitated the discovery of valuable drugs for the symptomatic
treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in …

Animal seizure and epilepsy models continue to play an important role in the early discovery
of new therapies for the symptomatic treatment of epilepsy. Since 1937, with the discovery of …

We postulate that “system epilepsies”(SystE) are due to an enduring propensity to generate
seizures of functionally characterized brain systems. Data supporting this hypothesis—that …

The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth,
differentiation, proliferation, and metabolism. Loss‐of‐function mutations in upstream …

Animal models have provided a wealth of information on mechanisms of epileptogenesis
and comorbidogenesis, and have significantly advanced our ability to investigate the …

Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …