An overview of spirooxindole as a promising scaffold for novel drug discovery
LM Zhou, RY Qu, GF Yang - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …
Keep calm and carry on with extra centrosomes
Simple Summary Precise chromosome segregation during mitosis is a vital event
orchestrated by formation of bipolar spindle poles. Supernumerary centrosomes, caused by …
orchestrated by formation of bipolar spindle poles. Supernumerary centrosomes, caused by …
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified …
Y Sun, Y Xue, P Sun, S Mu, H Liu, Y Sun… - Journal of Medicinal …, 2023 - ACS Publications
Polo-like kinase 4 (PLK4) is a master regulator of centriole replication and has been
proposed as a therapeutic target for multiple cancers, especially TRIM37-amplified breast …
proposed as a therapeutic target for multiple cancers, especially TRIM37-amplified breast …
CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis
Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality
worldwide. Here we described a genome-wide screen by CRISPR activation (CRISPRa) …
worldwide. Here we described a genome-wide screen by CRISPR activation (CRISPRa) …
Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase …
Z Ma, Y Sun, W Peng - Bioengineered, 2022 - Taylor & Francis
Fraxetin, a natural product isolated from herb Cortex Fraxini, has been demonstrated to
exhibit anti-cancer effects on various cancers. The aim of this work is to investigate the anti …
exhibit anti-cancer effects on various cancers. The aim of this work is to investigate the anti …
[HTML][HTML] Centrosomal-associated proteins: potential therapeutic targets for solid tumors?
Y Luan, M Li, Y Zhao, Q Li, J Wen, S Gao… - Biomedicine & …, 2021 - Elsevier
The centrosome is a special organelle in human cells and an organizing unit for
microtubules and signaling molecules. In addition, the centrosome is tightly restricted during …
microtubules and signaling molecules. In addition, the centrosome is tightly restricted during …
PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas
X Zhang, Z Li, C Wei, L Luo, S Li, J Zhou… - Frontiers in …, 2022 - frontiersin.org
Tumor immune microenvironment plays an important role in tumorigenesis and metastasis.
Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its …
Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its …
Radiotherapy and radiosensitization in breast cancer: Molecular targets and clinical applications
Relatively poor survival outcomes are observed in advanced or metastatic breast cancer,
where local control of the primary or metastatic disease may be achieved by surgical …
where local control of the primary or metastatic disease may be achieved by surgical …
Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation
FOA Frejat, H Zhai, Y Cao, L Wang, YA Mostafa… - Bioorganic …, 2022 - Elsevier
Indazole is a significant class of heterocyclic compounds with a wide range of biological
activity. We display here the synthesis and biological evaluation of a novel series of indazole …
activity. We display here the synthesis and biological evaluation of a novel series of indazole …
Hypoxia drives centrosome amplification in cancer cells via HIF1α-dependent induction of polo-like kinase 4
Centrosome amplification (CA) has been implicated in the progression of various cancer
types. Although studies have shown that overexpression of PLK4 promotes CA, the effect of …
types. Although studies have shown that overexpression of PLK4 promotes CA, the effect of …