XPA: DNA repair protein of significant clinical importance
L Borszéková Pulzová, TA Ward… - International journal of …, 2020 - mdpi.com
The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …
[HTML][HTML] The phenomenon of multidrug resistance in glioblastomas
AN Chernov, DA Alaverdian, ES Galimova… - … /Oncology and Stem Cell …, 2021 - Elsevier
The most common and aggressive brain tumor in the adult population is glioblastoma
(GBM). The lifespan of patients does not exceed 22 months. One of the reasons for the low …
(GBM). The lifespan of patients does not exceed 22 months. One of the reasons for the low …
miRNA-based technologies in cancer therapy
The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …
Examining SNP-SNP interactions and risk of clinical outcomes in colorectal cancer using multifactor dimensionality reduction based methods
Background: SNP interactions may explain the variable outcome risk among colorectal
cancer patients. Examining SNP interactions is challenging, especially with large datasets …
cancer patients. Examining SNP interactions is challenging, especially with large datasets …
[HTML][HTML] Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer
YK Li, Q Xu, LP Sun, YH Gong, JJ Jing… - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Single nucleotide polymorphisms (SNPs) are universally present in
nucleotide excision repair (NER) pathway genes, which could make impacts on colorectal …
nucleotide excision repair (NER) pathway genes, which could make impacts on colorectal …
Predicting drug response and toxicity in metastatic colorectal cancer: The role of germline markers
A Bignucolo, L Scarabel, G Toffoli… - Expert Review of …, 2022 - Taylor & Francis
Introduction Despite the introduction of targeted agents leading to therapeutic advances,
clinical management of patients with metastatic colorectal cancer (mCRC) is still challenged …
clinical management of patients with metastatic colorectal cancer (mCRC) is still challenged …
Genetic variants in DNA repair pathways as potential biomarkers in predicting treatment outcome of intraperitoneal chemotherapy in patients with colorectal peritoneal …
EC Hulshof, L Lim, IHJT de Hingh… - Frontiers in …, 2020 - frontiersin.org
Background: The introduction of cytoreductive surgery (CRS) followed by hyperthermic
intraperitoneal chemotherapy (HIPEC) with either oxaliplatin or mitomycin C for patients with …
intraperitoneal chemotherapy (HIPEC) with either oxaliplatin or mitomycin C for patients with …
[HTML][HTML] Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing
MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Saudi Journal of Biological …, 2021 - Elsevier
Background Pharmacogenetics is involved in customizing therapy according to the genetic
makeup of an individual, and is applicable for chemotherapy, radiotherapy as well as …
makeup of an individual, and is applicable for chemotherapy, radiotherapy as well as …
FBXW4 acts as a protector of FOLFOX-based chemotherapy in metastatic colorectal cancer identified by co-expression network analysis
Y Zhang, L Sun, X Wang, Y Sun, Y Chen, M Xu… - Frontiers in …, 2020 - frontiersin.org
Background FOLFOX chemotherapy is one of the most commonly used treatments for
colorectal cancer (CRC) patients. However, the efficacy and tolerance of FOLFOX therapy …
colorectal cancer (CRC) patients. However, the efficacy and tolerance of FOLFOX therapy …
Whole Exome Sequencing of a Patient with a Milder Phenotype of Xeroderma Pigmentosum Group C
JI Seo, C Nishigori, JJ Ahn, JY Ryu, J Lee, MH Lee… - Medicina, 2023 - mdpi.com
A 17-year-old female Korean patient (XP115KO) was previously diagnosed with Xeroderma
pigmentosum group C (XPC) by Direct Sanger sequencing, which revealed a homozygous …
pigmentosum group C (XPC) by Direct Sanger sequencing, which revealed a homozygous …