Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
EJ Sun, M Wankell, P Palamuthusingam, C McFarlane… - Biomedicines, 2021 - mdpi.com
Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …
Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products
Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …
high incidence, the clinical management of the disease remains a major challenge. Several …
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …
proliferation, growth and survival by the process of phosphorylation. Over activation of …
[HTML][HTML] Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies
E Pérez-Ruiz, I Melero, J Kopecka… - Drug Resistance …, 2020 - Elsevier
Cancer is one of the main public health problems in the world. Systemic therapies such as
chemotherapy and more recently target therapies as well as immunotherapy have improved …
chemotherapy and more recently target therapies as well as immunotherapy have improved …
Targeting PI3K/AKT/mTOR signaling pathway in pancreatic cancer: from molecular to clinical aspects
S Stanciu, F Ionita-Radu, C Stefani, D Miricescu… - International journal of …, 2022 - mdpi.com
Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …
its low incidence, it may become in the future one of the leading causes of cancer death …
Natural product-based nanomedicine: recent advances and issues
Natural products have been used in medicine for many years. Many top-selling
pharmaceuticals are natural compounds or their derivatives. These plant-or microorganism …
pharmaceuticals are natural compounds or their derivatives. These plant-or microorganism …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
Using ncRNAs as tools in Cancer diagnosis and treatment—the way towards personalized medicine to improve patients' health
Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …
years has the complexity of the transcriptome started to be elucidated. However, its …
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis
P Laissue - Molecular cancer, 2019 - Springer
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the
fourth most frequent cause of death having an oncological origin. It has been found that …
fourth most frequent cause of death having an oncological origin. It has been found that …
Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …