Structure and function of haemoglobins

DA Gell - Blood Cells, Molecules, and Diseases, 2018 - Elsevier
Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Nitric oxide reductases of prokaryotes with emphasis on the respiratory, heme–copper oxidase type

WG Zumft - Journal of inorganic biochemistry, 2005 - Elsevier
The investigation of respiratory N-oxide reduction as part of a biogeochemical process
sustained by prokaryotes has roots over a century ago and has laid the groundwork for …

Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases

PR Gardner - Journal of inorganic biochemistry, 2005 - Elsevier
Microbial flavohemoglobins (flavoHbs) and hemoglobins (Hbs) show large NO
dioxygenation rate constants ranging from 745 to 2900 μM− 1s− 1 suggesting a primal NO …

Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide

H Ouellet, Y Ouellet, C Richard… - Proceedings of the …, 2002 - National Acad Sciences
Mycobacterium tuberculosis, the causative agent of human tuberculosis, and Mycobacterium
bovis each express two genes, glbN and glbO, encoding distantly related truncated …

Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology

AD Frey, PT Kallio - FEMS microbiology reviews, 2003 - academic.oup.com
In response to oxygen limitation or oxidative and nitrosative stress, bacteria express three
kinds of hemoglobin proteins: truncated hemoglobins (tr Hbs), hemoglobins (Hbs) and …

[图书][B] Gene sharing and evolution: the diversity of protein functions

J Piatigorsky - 2007 - degruyter.com
This book explores gene sharing—a term originally coined to describe the observation that
structural proteins (called crystallins) responsible for the transparent and refractive …

[HTML][HTML] Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme

M Milani, A Pesce, Y Ouellet, P Ascenzi… - The EMBO …, 2001 - embopress.org
Macrophage‐generated oxygen‐and nitrogen‐reactive species control the development of
Mycobacterium tuberculosis infection in the host. Mycobacterium tuberculosis 'truncated …

Flavohemoglobin denitrosylase catalyzes the reaction of a nitroxyl equivalent with molecular oxygen

A Hausladen, A Gow… - Proceedings of the …, 2001 - National Acad Sciences
We have previously reported that bacterial flavohemoglobin (HMP) catalyzes both a rapid
reaction of heme-bound O2 with nitric oxide (NO) to form nitrate [HMP-Fe (II) O2+ NO→ HMP …

Protection from nitrosative stress: a central role for microbial flavohemoglobin

MT Forrester, MW Foster - Free Radical Biology and Medicine, 2012 - Elsevier
Nitric oxide (NO) is an inevitable product of life in an oxygen-and nitrogen-rich environment.
This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating …

Hemoglobins dioxygenate nitric oxide with high fidelity

PR Gardner, AM Gardner, WT Brashear… - Journal of Inorganic …, 2006 - Elsevier
Distantly related members of the hemoglobin (Hb) superfamily including red blood cell Hb,
muscle myoglobin (Mb) and the microbial flavohemoglobin (flavoHb) dioxygenate nitric …