Estradiol is the most potent and ubiquitous member of a class of steroid hormones called
estrogens. Fetuses and newborns are exposed to estradiol derived from their mother, their …

Steroid hormones exert profound effects on cell growth, development, differentiation, and
homeostasis. Their effects are mediated through specific intracellular steroid receptors that …

Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

Using cDNA cloning strategies commonly employed for G protein-coupled receptors
(GPCR), GPCR-30 (GPR30), was isolated from mammalian cells before knowledge of its …

Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas …

Estrogen plays an important role in the regulation of cardiovascular physiology and the
immune system by inducing direct effects on multiple cell types including immune and …

Estrogen is a hormone critical in the development, normal physiology and pathophysiology
of numerous human tissues. The effects of estrogen have traditionally been solely ascribed …

In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor
Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human …

Gender differences in schizophrenia have been extensively researched and it is being
increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of …

Estrogen is central to many physiological processes throughout the human body. We have
previously shown that the G protein–coupled receptor GPR30 (also known as GPER), in …