In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is an essential component of
transcriptional regulation and RNA processing of protein-coding genes. A large body of data …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

We studied regulation of human immunodeficiency virus-l (HIV-i) transcription by Tat and, for
comparative purposes, by the adenovirus EiA protein. These two frans-activators exerted …

Fit‐1 has been identified previously as a Fos‐responsive gene of rat fibroblasts. Here we
show that Fit‐1 is directly regulated by the estrogen‐inducible transcription factor Fos‐ER …

We investigated co-transcriptional recruitment of pre-mRNA processing factors to human
genes. Capping factors associate with paused RNA polymerase II (pol II) at the 5′ ends of …