Abstract The type I IFN (IFN‐I) system is essential to limit severe viral disease in humans.
Thus, IFN‐I deficiencies are associated with serious life‐threatening infections. Remarkably …

Abstract SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals.
Human studies indicate these T cells could be elicited by the common cold coronavirus …

Purpose To study the effect of interferon-α2 auto-antibodies (IFN-α2 Abs) on clinical and
virological outcomes in critically ill COVID-19 patients and the risk of IFN-α2 Abs transfer …

Abstract Background Type I interferons (IFNs) are essential antiviral cytokines induced upon
respiratory exposure to coronaviruses. Defects in type I IFN signaling can result in severe …

Antiviral type I interferons (IFN) produced in the early phase of viral infections effectively
inhibit viral replication, prevent virus-mediated tissue damages and promote innate and …

Update on human genetic susceptibility to COVID-19: susceptibility to virus and response |
Human Genomics Skip to main content SpringerLink Account Menu Find a journal Publish with …

Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of
the major complications in COVID-19 patients. Dysregulation of the immune system and …

Respiratory infections with newly emerging zoonotic viruses such as SARS-CoV-2, the
etiological agent of COVID-19, often lead to the perturbation of the human innate and …

SARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical
presentation of acute infection varies greatly between individuals, ranging from …

Highlights•The incompletely penetrant association of IL-17/IL-22 AAbs with CMC and
evidence from clinical IL-17 mAbs and genetic IL-10RB deficiency imply these AAbs may not …