Even within a single protein, antibody binding can have beneficial, neutral, or harmful effects
during the response to infection. Resolving a polyclonal antibody repertoire across a …

Purpose Six-19% of critically ill COVID-19 patients display circulating auto-antibodies
against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for …

Das schwere akute respiratorische Syndrom Coronavirus 2 (SARS-CoV-2), der Erreger der
Coronavirus-Krankheit 2019 (COVID-19), wurde schnell zu einer Pandemie und hat seit …

ABSTRACT SARS-CoV-2-induced impaired antiviral and excessive inflammatory responses
cause fatal pneumonia. However, the key pattern recognition receptors that elicit effective …

Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been
associated with pre-disposition to severe COVID-19. Here, we screened for such …

Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning
antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting …

UC San Francisco Previously Published Works Page 1 UCSF UC San Francisco Previously
Published Works Title Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …

Respiratory infections with newly emerging zoonotic viruses such as SARS-CoV-2, the
etiological agent of COVID-19, often lead to the perturbation of the human innate and …

Primary adrenal insufficiency (PAI) is a rare disease leading to deficient secretion of adrenal
steroid hormones. The causes and incidence of PAI vary in different populations and age …