Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic
inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment …

Platelet production, maintenance, and clearance are tightly controlled processes indicative
of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for …

Genetics studies have identified the gene for the high-affinity IgE receptor (FcεRI) β subunit
as a candidate gene for atopy. We have shown that β is an intrinsic signaling amplifier …

Publisher Summary This chapter discusses about existing as well as more recent
information pertaining to the biology of human basophils with particular emphasis on the …

IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE
can undeniably play an important role in mediating allergic reactions; best exemplified by …

Atopic diseases such as asthma, rhinitis, eczema and food allergies have increased in most
industrialised countries of the world during the last 20 years. The reasons for this increase …

Disparate sister compounds: Despite their similarity, significantly different strategies were
necessary to bring the individual members of the aspercyclide family into reach. Whereas …

Natural cytotoxicity receptors (NCR) mediate lysis of a variety of tumor and virus-infected
cells by natural killer (NK) cells. Upon engagement, NCR trigger the cytolytic activity and …