N‐Nitrosamine (NA) impurities are considered genotoxic and have gained attention due to
the recall of several marketed drug products associated with higher‐than‐permitted limits of …

The popularity of botanical and other purported medicinal natural products (NPs) continues
to grow, especially among patients with chronic illnesses and patients managed on complex …

This chapter introduces xenobiotic metabolism (in this chapter, the terms “xenobiotic
metabolism” and “xenobiotic-metabolizing enzyme” will be used in preference to “drug …

Long-term use of imatinib is effective and well-tolerated in children with chronic myeloid
leukaemia (CML) yet defining an optimal dosing regimen for imatinib in younger patients is a …

Aims This study implements a physiologically‐based pharmacokinetic (PBPK) modelling
approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing …

Aims Herbal products, spices and/or fruits are perceived as inherently healthy; for instance,
St. John's wort (SJW) is marketed as a natural antidepressant and patients often self …

We aimed to use physiologically based pharmacokinetic (PBPK) modeling and simulation to
predict imatinib steady‐state plasma exposure in patients with chronic myeloid leukemia …

Schisandra chinensis has been widely used as a traditional herbal medicine to treat chronic
coughs, fatigue, night sweats, and insomnia. Numerous bioactive components including …

Purpose This study aimed to investigate the potential pharmacokinetic interactions between
curcumin, imatinib and bosutinib, combining In Vitro and in silico methods. Methods In Vitro …

This study was designed to develop and validate a 10 probe drug cocktail named “Dual
Cocktail”, composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac …