Simple Summary Mucociliary clearance constitutes an innate lung defense mechanism that
is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways …

A key aspect of the lung's innate defense system is the ability of the superficial epithelium to
regulate airway surface liquid (ASL) volume to maintain a 7-μm periciliary liquid layer (PCL) …

Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by
a highly developed innate defense system. Physiologically regulated epithelial ion and …

In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and
inflammation. However, cilia beating features in a CF altered environment, consisting of …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Many epithelia, including the superficial epithelia of the airways, are thought to secrete
“volume sensors,” which regulate the volume of the mucosal lining fluid. The epithelial Na+ …

Effective clearance of mucus is a critical innate airway defense mechanism, and under
appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has …

Extracellular ATP and its metabolite adenosine regulate mucociliary clearance in airway
epithelia. Little has been known, however, regarding the actual ATP and adenosine …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease
characterized by patchy scarring of the distal lung with limited therapeutic options and poor …

The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …