Dysregulated protease activity has long been implicated in the pathogenesis of chronic lung
diseases and especially in conditions that display mucus obstruction, such as chronic …

The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway
surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within …

In vitro cultures of primary human airway epithelial cells (hAECs) grown at air–liquid
interface have become a valuable tool to study airway biology under normal and pathologic …

Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …

Extracellular ATP controls key aspects of lung function via activation of epithelial cell
purinergic receptors, but how ATP is released from cells remains poorly understood. To …

Rationale The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-
activated Chloride Conductance (CaCC) each play critical roles in maintaining normal …

Improved understanding of structure and function relationships in the human lungs in
individuals and subpopulations is fundamentally important to the future of pulmonary …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. Although impairment of mucociliary clearance …

The airflow characteristics in a computed tomography (CT) based human airway bifurcation
model with rigid and compliant walls are investigated numerically. An in-house three …

Allergic sensitization is the outcome of a complex interplay between the allergen and the
host in a given environmental context. The first barrier encountered by an allergen on its way …