Dehydration of the airways results in release of mediators. The likely source of these
mediators is the mast cell. Epithelial injury occurs in exercise-induced bronchoconstriction …

Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA
compacted with block copolymers of poly-l-lysine and 10kDa polyethylene glycol …

Mucociliary clearance (MCC) is an important innate defense mechanism that continuously
removes inhaled pathogens and particulates from the airways. Normal MCC is essential for …

Ciliary beat frequency (CBF) is a key factor in the defense of the airways, and ATP can
stimulate CBF by increasing intracellular calcium concentration ([Ca2+] i). However, the …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

Respiratory viruses remain a significant cause of morbidity and mortality in the human
population, underscoring the importance of ongoing basic research into virus–host …

The role of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in airway
epithelial wound repair was investigated using normal human bronchial epithelial (NHBE) …

Background Respiratory syncytial virus infection causes acute lung infection in infants and
young children worldwide, resulting in considerable morbidity and mortality. Children with …

Rationale: Pulmonary infections can impair alveolar fluid clearance (AFC), contributing to
formation of lung edema. Effects of influenza A virus (IAV) on AFC are unknown. Objectives …

A balance sheet describing the integrated homeostasis of secretion, absorption, and surface
movement of liquids on pulmonary surfaces has remained elusive. It remains unclear …