Cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians, affects
approximately 70 000 individuals worldwide. In 1998, the Cystic Fibrosis Foundation (CFF) …

Despite remarkable progress following the identification of the causing gene, the final
outcome of cystic fibrosis (CF) remains determined mainly by the progressive reduction of …

Significant progress has been achieved in developing precision therapies for cystic fibrosis;
however, highly effective treatments that target the ion channel, CFTR, are not yet available …

The mucociliary clearance system is comprised of three components, ion transport activities
controlling the height of airway surface liquid (ASL), mucin secretion, and ciliary activity …

Inhaled hypertonic saline as a therapy for cystic fibrosis : Current Opinion in Pulmonary
Medicine Inhaled hypertonic saline as a therapy for cystic fibrosis : Current Opinion in …

Abstract The epithelial Na+ channel (ENaC) is the rate-limiting step for Na+ absorption in
various vertebrate epithelia and deeply enmeshed in the control of salt and water …

Mucociliary clearance is a biomechanical mechanism of airway protection. It consists of the
active transport along the bronchial tree of the mucus, a fluid propelled by the coordinated …

Exposure of lung airways to detrimental suspended aerosols in the environment increases
the vulnerability of the respiratory and cardiovascular systems. In addition, recent …

Exhaled breath condensate (EBC) analyses promise simple and noninvasive methods to
measure airway biomarkers but pose considerable methodological challenges. We utilized …

Thiazide and loop diuretics induce renal K+ secretion, often leading to renal K+ wasting and
hypokalemia. This phenomenon has been proposed to reflect an increase in delivery to and …