Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
[HTML][HTML] Depression and pain: use of antidepressants
H Bonilla-Jaime, JA Sánchez-Salcedo… - Current …, 2022 - ncbi.nlm.nih.gov
Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …
Human spinal organoid-on-a-chip to model nociceptive circuitry for pain therapeutics discovery
The discovery of new pain therapeutics targeting human nociceptive circuitry is an
emerging, exciting, and rewarding field. However, current models for evaluating prospective …
emerging, exciting, and rewarding field. However, current models for evaluating prospective …
[HTML][HTML] IUPHAR review: Navigating the role of preclinical models in pain research
Chronic pain is a complex and challenging medical condition that affects millions of people
worldwide. Understanding the underlying mechanisms of chronic pain is a key goal of …
worldwide. Understanding the underlying mechanisms of chronic pain is a key goal of …
[HTML][HTML] Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain
Attention-deficit/hyperactivity disorder (ADHD) and pathological pain are two complex
syndromes of multifactorial origin. Despite their prevalence and broad impacts, these …
syndromes of multifactorial origin. Despite their prevalence and broad impacts, these …
[HTML][HTML] Stress circuitry: mechanisms behind nervous and immune system communication that influence behavior
Inflammatory processes are increased by stress and contribute to the pathology of mood
disorders. Stress is thought to primarily induce inflammation through peripheral and central …
disorders. Stress is thought to primarily induce inflammation through peripheral and central …
Micro-and nanocarriers for pain alleviation
A da Silva, S Lepetre-Mouelhi, P Couvreur - Advanced Drug Delivery …, 2022 - Elsevier
Acute or chronic pain is a major source of impairment in quality of life and affects a
substantial part of the population. To date, pain is alleviated by a limited range of treatments …
substantial part of the population. To date, pain is alleviated by a limited range of treatments …
Reproducibility, relevance and reliability as barriers to efficient and credible biomedical technology translation
Biomedical research accuracy and relevance for improving healthcare are increasingly
identified as costly problems. Basic research data quality, reporting and methodology, and …
identified as costly problems. Basic research data quality, reporting and methodology, and …
The potential protective effects of pre-injury exercise on neuroimmune responses following experimentally-induced traumatic neuropathy: a systematic review with …
MA Koop, MLS Sleijser-Koehorst… - Frontiers in …, 2023 - frontiersin.org
Pre-clinical evidence shows that neuropathy is associated with complex neuroimmune
responses, which in turn are associated with increased intensity and persistence of …
responses, which in turn are associated with increased intensity and persistence of …
A multi-ancestry genetic study of pain intensity in 598,339 veterans
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …
pain daily or on most days. It adversely affects the quality of life and imposes substantial …