Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases,
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …

Two genetic variants that alter alcohol metabolism, ALDH2‐rs671 and ADH1B‐rs1229984,
can modify oesophageal cancer risk associated with alcohol consumption in East Asians …

Background ADH1B rs1229984 and ALDH2 rs671 are the specifically prevalent functional
variants in the East Asians. These variants, which result in a dramatic change in enzyme …

Background: The different pharmacological effects of drugs in different people can be
explained by the polymorphisms of drug metabolism-related genes. Emerging studies have …

OBJECTIVES The purpose of this study was to determine the causal relationship between
the genetically determined amount of alcohol consumption and the occurrence of major …

OBJECTIVES Elevated C-reactive protein (CRP) levels are associated with an increased
risk for colorectal cancer (CRC), as well as a poor prognosis, but it remains unclear whether …

Background Hashimoto's thyroiditis (HT) is a chronic autoimmune disease that poses a risk
factor for papillary thyroid carcinoma (PTC). The present study aimed to identify the key …

Breast cancer (BRCA) is a serious life-threatening cancer, especially triple-negative breast
cancer (TNBC). Alcohol dehydrogenase-1B (ADH1B) has recently been revealed to be …

Purpose Colorectal cancer (CRC) is among the most common cancers worldwide and an
important cause of cancer-related death. Inherited genetic variation plays a vital role in the …

Interferon regulatory factor (IRF) family genes play a critical role in colorectal cancer (CRC)
development and impact patient survival. This study evaluated the influence of functional …