Alcohol metabolism causes hepatocytes to release damage‐associated molecular patterns
(DAMPs). This includes mitochondrial DNA (mtDNA), which is generated and released from …

Background Retinal neurodegeneration is induced by a variety of environmental insults and
stresses, but the exact mechanisms are unclear. In the present study, we explored the …

Excessive acetaminophen (APAP) can induce neutrophil activation and hepatocyte death.
Along with hepatocyte dysfunction and death, NETosis (a form of neutrophil-associated …

Background & Aims Sustained c-Jun N-terminal kinase (JNK) activation plays a major role in
drug-induced liver injury (DILI). Stress-responsive microRNA-31 (miR-31) has been …

Mitochondria are organelles that are essential for cellular homeostasis including energy
harvesting through oxidative phosphorylation. Mitochondrial dysfunction plays a vital role in …

A recent study suggests that voltage‐dependent anion channel (VDAC) oligomer pores
promote mitochondrial outer membrane permeabilization and allow mitochondrial DNA …

The global epidemic of metabolic diseases has led to the emergence of metabolic
dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction …

Prolonged exposure to bullying behaviors may give rise to symptoms such as anxiety,
depression and chronic pain. Earlier data suggest that these symptoms often are associated …

The differential microRNA (miRNA) omics of the synovial membrane were investigated using
a rat model of knee osteoarthritis (KOA) induced by bilateral anterior cruciate ligament …

Introduction Morbidity and mortality from liver disease continues to rise worldwide. There are
currently limited curative treatments for patients with liver failure syndromes, encompassing …