The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Melanoma develops from malignant transformations of the pigment-producing melanocytes.
If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous …

Antioxidants in the diet and supplements are widely used to protect against cancer, but
clinical trials with antioxidants do not support this concept. Some trials show that …

The common mutation BRAFV600 in primary melanomas activates the mitogen-activated
protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the …

Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting
from constitutive pigmentation variability. This paper will review the characterization of skin …

UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …