Objective: Oxygen is vital during critical illness, but hyperoxia may harm patients. Our aim
was to systematically evaluate the methodology and findings of cohort studies investigating …

Introduction The safety of arterial hyperoxia is under increasing scrutiny. We performed a
systematic review of the literature to determine whether any association exists between …

Importance Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal
oxygenation targets are unknown. Objective To determine whether a low-normal Pao 2 …

Background Optimal oxygen targets in patients resuscitated after cardiac arrest are
uncertain. The primary aim of this study was to describe the values of partial pressure of …

This review summarizes the (patho)-physiological effects of ventilation with high FiO 2 (0.8–
1.0), with a special focus on the most recent clinical evidence on its use for the management …

Oxygen treatment has been a cornerstone of acute medical care for numerous pathological
states. Initially, this was supported by the assumed need to avoid hypoxaemia and tissue …

Background Providing supplemental oxygen is fundamental in the management of
mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes …

Extracorporeal CPR is a second line treatment for refractory cardiac arrest, as written in the
latest International Guidelines. Optimal timing, patient selection, location and method of …

Background In clinical practice, oxygen is generally administered to patients with the
intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial …

Background: Exposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may
be associated with worse outcomes in patients receiving extracorporeal membrane …