Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality.
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …

Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …

Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as a promising
alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect …

Brain tumors, especially glioblastoma, remain the most aggressive form of all the cancers
because of inefficient diagnosis and profiling. Nanostructures, such as metallic …

Currently, biological membrane-derived nanoparticles (NPs) have shown enormous
potential as drug delivery vehicles due to their outstanding biomimetic properties. To make …

Bioorthogonal click chemistry, first introduced in the early 2000s, has become one of the
most widely used approaches for designing advanced biomaterials for applications in tissue …

The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Glioblastoma is one of the most aggressive central nervous system malignancies with high
morbidity and mortality. Current clinical approaches, including surgical resection …