Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Ventilator-associated pneumonia in adults: a narrative review

L Papazian, M Klompas, CE Luyt - Intensive care medicine, 2020 - Springer
Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections.
Reported incidences vary widely from 5 to 40% depending on the setting and diagnostic …

The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation

CN Kotton, D Kumar, AM Caliendo, S Huprikar… - …, 2018 - journals.lww.com
Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common
complications affecting solid organ transplant recipients, conveying higher risks of …

Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European …

P Ljungman, R de la Camara, C Robin… - The Lancet infectious …, 2019 - thelancet.com
Cytomegalovirus is one of the most important infections to occur after allogeneic
haematopoietic stem cell transplantation (HSCT), and an increasing number of reports …

High incidence of Epstein–Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

A Simonnet, I Engelmann, AS Moreau, B Garcia… - Infectious Diseases …, 2021 - Elsevier
Background Systemic reactivation of herpesviruses may occur in intensive care unit (ICU)
patients and is associated with morbidity and mortality. Data on severe Coronavirus disease …

Epidemiology and immune pathogenesis of viral sepsis

GL Lin, JP McGinley, SB Drysdale… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …

Surviving sepsis campaign: research priorities for sepsis and septic shock

CM Coopersmith, D De Backer, CS Deutschman… - Intensive care …, 2018 - Springer
Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Pulmonary infections complicating ARDS

CE Luyt, L Bouadma, AC Morris, JA Dhanani… - Intensive care …, 2020 - Springer
Pulmonary infection is one of the main complications occurring in patients suffering from
acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of …

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality

I Gatto, E Biagioni, I Coloretti, C Farinelli, C Avoni… - Intensive care …, 2022 - Springer
Purpose Cytomegalovirus (CMV) reactivation in immunocompetent critically ill patients is
common and relates to a worsening outcome. In this large observational study, we …

Why the elderly appear to be more severely affected by COVID‐19: the potential role of immunosenescence and CMV

S Kadambari, P Klenerman… - Reviews in medical …, 2020 - Wiley Online Library
The significantly higher mortality rates seen in the elderly compared with young children
during the coronavirus disease 2019 (Covid‐19) pandemic is likely to be driven in part by an …