For the treatment of malignancy, many therapeutic agents, including small molecules,
photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded …

Gene therapy involves the introduction of foreign genetic material into cells in order exert a
therapeutic effect. The application of gene therapy to the field of orthopaedic tissue …

Here, we report the synthesis and characterization of size-controllable and stimuli-
responsive DNA nanohydrogels as effective targeted gene delivery vectors. DNA …

Gene therapy offers the potential of mediating disease through modification of specific
cellular functions of target cells. However, effective transport of nucleic acids to target cells …

The cationizable nature of 'proton-sponge'transfection agents facilitates pDNA delivery in
several steps. Protonated amines account for electrostatic DNA binding and cellular uptake …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

The science of gene therapy has experienced a controversial history. At first, the initial
concept that various disorders become curable by gene transferring was very exciting and …

Over the last several years, various gene delivery systems have been developed for gene
therapy applications. Although viral vector-based gene therapy has led to the greatest …

In the biopharmaceutical industry, mammalian and insect cells as well as plant cell cultures
are gaining worldwide importance to produce biopharmaceuticals and as products …

The unraveling of cellular apoptosis machinery provides novel targets for cancer treatment,
and gene therapy targeting this suicidal system has been corroborated to cause …