Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …

Cryopreservation has facilitated advancement of biological research by allowing the storage
of cells over prolonged periods of time. While cryopreservation at extremely low …

▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

Nitric oxide (NO) is a free radical found at higher than normal concentrations within
inflammatory multiple sclerosis (MS) lesions. These high concentrations are due to the …

Abstract Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …

This review summarises the role that reactive oxygen and nitrogen species play in
demyelination, such as that occurring in the inflammatory demyelinating disorders multiple …

Death of oligodendrocyte (OL) precursors can be triggered in vitro by cystine deprivation, a
form of oxidative stress that involves depletion of intracellular glutathione. We report here …

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …

In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in
treating stroke, with the exception of thrombolytics. Although many targets have been …