Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The spread of carbapenemase producers in Enterobacteriaceae has now been identified
worldwide. Three main carbapenemases have been reported; they belong to three classes …

We describe the global molecular epidemiology of 229 carbapenemase-producing
Escherichia coli in 36 countries during 2015–2017. Common carbapenemases were …

Antibiotic resistance is one of the biggest challenges for the clinical sector and industry,
environment and societal development. One of the most important pathogens responsible …

The emergence of carbapenem-resistant enterobacterial species poses a serious threat to
public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are …

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense
against multidrug‐resistant Gram‐negative organisms. Over the last decade, carbapenem …

Background Klebsiella species, including the notable pathogen K. pneumoniae, are
increasingly associated with antimicrobial resistance (AMR). Genome-based surveillance …

Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human
health. CRE that are non-susceptible to all commercially available antibiotics threaten to …