Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Microplastics (MP) are receiving increased attention as a harmful environmental pollutant,
however information on the reproduction toxicity of MP in terrestrial animals, especially …

The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

Vascular cognitive impairment and dementia (VCID) is a major heterogeneous brain
disease caused by multiple factors, and it is the second most common type of dementia in …

Dry eye disease (DED) impacts≈ 30% of the world's population and causes serious ocular
discomfort and even visual impairment. Inflammation is one core cause of the DED vicious …

Abstract PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules
that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted …

The ASK1-signalosome→ p38 MAPK and SAPK/JNK signaling networks promote
senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to …

Ethnopharmacological relevance Plant essential oils (PEOs) extracted from aromatic
compounds of the plant contain complex mixtures of volatile and lipophilic bioactive …

Natural dietary agents have attracted considerable attention due to their role in promoting
health and reducing the risk of diseases including cancer. Ginger, one of the most ancient …