Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Abstract Background Approximately 8–9% of the world's population is affected by
autoimmune diseases, and yet the mechanism of autoimmunity trigger is largely …

Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide
accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative …

Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

As an iron-dependent mode of programmed cell death induced by lipid peroxidation,
ferroptosis plays an important role in cancer therapy. The metabolic reprogramming in tumor …

A potential reason for the failure of tumor therapies is treatment resistance. Resistance to
chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic …

Regulated cell death (RCD) is a vital event in various physiological and pathological
processes. Ferroptosis is a newly described RCD, which is driven by iron accumulation and …

Ferroptosis holds great potential in cancer treatment, but its efficacy is severely limited by a
low Fenton reaction efficacy. Meanwhile, the interactive relationship between Ferroptosis …

Iron is an important metal element involved in the regulation of male reproductive functions
and has dual effects on testicular tissue. A moderate iron content is necessary to maintain …