The asthma–COPD overlap syndrome

DS Postma, KF Rabe - New England Journal of Medicine, 2015 - Mass Medical Soc
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[HTML][HTML] COPD immunopathology

G Caramori, P Casolari, A Barczyk, AL Durham… - Seminars in …, 2016 - Springer
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the
innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette …

Total and state-specific medical and absenteeism costs of COPD among adults aged 18 years in the United States for 2010 and projections through 2020

ES Ford, LB Murphy, O Khavjou, WH Giles, JB Holt… - Chest, 2015 - Elsevier
BACKGROUND COPD remains a leading cause of morbidity and mortality. The objectives of
this study were to estimate (1) national US COPD-attributable annual medical costs by payer …

Asthma–COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease

SA Christenson, K Steiling… - American journal of …, 2015 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and
likely includes a subgroup that is biologically comparable to asthma. Studying asthma …

Age-specific associations of ozone and fine particulate matter with respiratory emergency department visits in the United States

HM Strosnider, HH Chang, LA Darrow… - American journal of …, 2019 - atsjournals.org
Rationale: Whereas associations between air pollution and respiratory morbidity for adults
65 years and older are well documented in the United States, the evidence for people under …

Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD

ET Osei, CA Brandsma, W Timens… - European …, 2020 - Eur Respiratory Soc
Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and
mortality worldwide. In the context of disease pathogenesis, both asthma and COPD involve …

Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease

YS Prakash - American Journal of Physiology-Lung Cellular …, 2016 - journals.physiology.org
Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

[HTML][HTML] Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with …

RA Hartley, BL Barker, C Newby, M Pakkal… - Journal of Allergy and …, 2016 - Elsevier
Background There is a paucity of studies comparing asthma and chronic obstructive
pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) …

Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease

SE D'Anna, M Maniscalco, F Cappello… - Annals of …, 2021 - Taylor & Francis
In chronic obstructive pulmonary disease (COPD) patients, bacterial and viral infections play
a relevant role in worsening lung function and, therefore, favour disease progression. The …

The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease

SLI Wong, MB Sukkar - British journal of pharmacology, 2017 - Wiley Online Library
The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule
regulating interactions between cells and their surrounding extracellular matrix (ECM). This …