[HTML][HTML] Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose

G Sanchez-Guerrero, DS Umbaugh… - Livers, 2023 - mdpi.com
The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled
receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several …

A novel pathway of functional microRNA uptake and mitochondria delivery

J Liu, W Li, J Li, E Song, H Liang, W Rong… - Advanced …, 2023 - Wiley Online Library
Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake
of extracellular miRNAs by recipient cells and their intracellular transport, however, remains …

[PDF][PDF] 对乙酰氨基酚致肝损伤的线粒体机制研究进展

伍敏, 金虹, 李可欣, 汪晓寒… - 中国药理学与毒理学 …, 2023 - cjpt.magtechjournal.com
对乙酰氨基酚(APAP) 是临床上常用的解热镇痛药物, 过量使用可导致严重肝损伤.
肝富含线粒体, 越来越多的研究提示线粒体在APAP 诱导的肝损伤中发挥重要作用. APAP …

[HTML][HTML] Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury

H Wu, X Bao, AH Gutierrez… - Exploration of …, 2023 - explorationpub.com
The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research.
However, investigators have shown that both oxidative stress and endoplasmic reticulum …