Drug-induced liver injury

RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Hepatotoxicity due to herbal dietary supplements: Past, present and the future

BJ Gurley, MR McGill, I Koturbash - Food and Chemical Toxicology, 2022 - Elsevier
Dietary supplements (DS) constitute a widely used group of products comprising vitamin,
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …

[PDF][PDF] Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: an international collaborative effort

RJ Church, GA Kullak‐Ublick, J Aubrecht… - …, 2019 - Wiley Online Library
Current blood biomarkers are suboptimal in detecting drug‐induced liver injury (DILI) and
predicting its outcome. We sought to characterize the natural variabilty and performance …

Visceral Adipose Tissue Derived Exosomes Exacerbate Colitis Severity via Pro-inflammatory MiRNAs in High Fat Diet Fed Mice

M Wei, X Gao, L Liu, Z Li, Z Wan, Y Dong, X Chen… - ACS …, 2020 - ACS Publications
A pioneering epidemic study has revealed a strong association between obesity and the risk
of colitis. In this study, a high fat diet was found to significantly aggravate colitis induced by …

[HTML][HTML] Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p

J Lou, J Wu, M Feng, X Dang, G Wu, H Yang… - Journal of Sport and …, 2022 - Elsevier
Background Angiogenesis constitutes a major mechanism responsible for exercise-induced
beneficial effects. Our previous study identified a cluster of differentially expressed …

[HTML][HTML] Anemia of geriatric patients

K Gadó, M Khodier, A Virág, G Domján… - Physiology …, 2022 - akjournals.com
Anemia is a common finding in the elderly. Approximately 10 percent of the elderly suffers
from anemia. Anemia per se is an independent factor of mortality in older patients regardless …

The transformation in biomarker detection and management of drug‐induced liver injury

RJ Church, PB Watkins - Liver International, 2017 - Wiley Online Library
Drug‐induced liver injury (DILI) is a major concern for patients, care givers and the
pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and …

Anemia in older adults as a geriatric syndrome: A review

A Katsumi, A Abe, S Tamura… - Geriatrics & gerontology …, 2021 - Wiley Online Library
Anemia, a frequently occurring condition in older patients, has no standard definition;
however, in most studies, it is defined as hemoglobin level< 12 and< 13 g/dL in women and …

[HTML][HTML] The role of inflammation in age-associated changes in red blood system

E Wacka, E Wawrzyniak-Gramacka, A Tylutka… - International journal of …, 2023 - mdpi.com
Aging-related anemia contributes to frailty syndrome, cognitive decline and early mortality.
The study aim was to evaluate inflammaging in relation to anemia as a prognostic indicator …

Metabolic circuit involving free fatty acids, microRNA 122, and triglyceride synthesis in liver and muscle tissues

C Chai, M Rivkin, L Berkovits, A Simerzin… - Gastroenterology, 2017 - Elsevier
Background & Aims Effective treatments are needed for hepatic steatosis characterized by
accumulation of triglycerides in hepatocytes, which leads to hepatocellular carcinoma …