Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other
chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia …

In the present study, the protective effects of quercetin on peripheral neurotoxicity caused by
vincristine, which is used effectively in the treatment of various types of cancers, were …

Chemotherapy drugs such as vincristine (Vin) could cause neuropathic pain. However, it is
still lack of ideal therapeutic strategy to treat it. Mitochondrial dysfunction has been involved …

Disclosures: K. Schroder reported" other" from Inflazome Ltd outside the submitted work; in
addition, K. Schroder had a patent to PCT/EP2017/053498 licensed (Inflazome Ltd), a patent …

The Notch signaling pathway is mainly involved in the regulation of neural stem cell
proliferation, survival and differentiation during the development of the central nervous …

The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110
years ago and has been found to play a crucial role in the development of multicellular …

Despite the rapid advance over the past decades to design effective therapeutic
pharmacological interventions, chronic pain remains to be an unresolved healthcare …

Background and Purpose Neuropathic pain is a major side-effect of paclitaxel (PTX)
chemotherapy. Although the precise mechanisms responsible for this pain are unclear, the …

Paclitaxel-induced neuropathic pain (PINP) is a progressive and refractory side effect of
chemotherapy with few effective treatments at present. It is well-established that astrocytes …