Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

In recent years, conventional treatments including surgery, chemotherapy and radiotherapy
have been the main approaches in tumour therapy. Cancer immunotherapy is a new …

The vast opportunities for biomaterials design and functionality enabled by mimicking nature
continue to stretch the limits of imagination. As both biological understanding and …

Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …

The continued evolution of biomedical nanotechnology has enabled clinicians to better
detect, prevent, manage, and treat human disease. In order to further push the limits of …

Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …

In recent years, the continuous development of magnetic nanostructures (MNSs) has
tremendously promoted both fundamental scientific research and technological applications …

Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …