Introduced in the late 1950s, polyenes represent the oldest family of antifungal drugs. The
discovery of amphotericin B and its therapeutic uses is considered one of the most important …

Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which
therapeutic options are limited, we conducted a retrospective study including 91 patients …

Posaconazale is a new triazole drug being investigated in phase III clinical trials for the
treatment and prevention of invasive fungal infections. In-vitro and in-vivo studies showed …

Abstract Background. Mycograb (Neu Tec Pharma) is a human recombinant monoclonal
antibody against heat shock protein 90 that, in laboratory studies, was revealed to have …

Antifungal susceptibility testing is a very dynamic field of medical mycology. Standardization
of in vitro susceptibility tests by the Clinical and Laboratory Standards Institute (CLSI) and …

Invasive fungal infections (IFIs) remain an important cause of morbidity and mortality in
patients with acute or chronic leukemia. Advances in the pharmacotherapy of fungal …

Cutaneous fungal infections affect more than one-fourth of world's population. The
pathogenesis and severity of fungal infection depend on various immunological and …

Systemic fungal infections are associated with high mortality rates despite adequate
treatment. Moreover, acquired resistance to antifungals is increasing, which further …