[HTML][HTML] Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides

X Luo, H Chen, Y Song, Z Qin, L Xu, N He, Y Tan… - European Journal of …, 2023 - Elsevier
Among other health related issues, the rising concerns on drug resistance led to look for
alternative pharmaceutical drugs that are effective both against infectious and noninfectious …

[HTML][HTML] Modulating the blood–brain barrier: a comprehensive review

R Whelan, GC Hargaden, AJS Knox - Pharmaceutics, 2021 - mdpi.com
The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …

[HTML][HTML] In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria

P Askari, MH Namaei, K Ghazvini… - BMC Pharmacology and …, 2021 - Springer
Background Melittin is one of the most studied antimicrobial peptides, and several in vitro
experiments have demonstrated its antibacterial efficacy. However, there is evidence …

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

BG Eid, NA Alhakamy, UA Fahmy, OAA Ahmed… - Pharmacological …, 2022 - Elsevier
A dysregulation of the wound healing process can lead to the development of various
intractable ulcers or excessive scar formation. Therefore it is essential to identify novel …

[HTML][HTML] Antimicrobial, Antibiofilm, and Anti-persister Activities of Penfluridol Against Staphylococcus aureus

Y Liu, P She, L Xu, L Chen, Y Li, S Liu, Z Li… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus has increasingly attracted global attention as a major opportunistic
human pathogen owing to the emergence of biofilms (BFs) and persisters that are known to …

[HTML][HTML] Antibiofilm effect of melittin alone and in combination with conventional antibiotics toward strong biofilm of MDR-MRSA and -Pseudomonas aeruginosa

R Mirzaei, H Esmaeili Gouvarchin Ghaleh… - Frontiers in …, 2023 - frontiersin.org
Introduction Multidrug-resistant (MDR) pathogens are being recognized as a critical threat to
human health if they can form biofilm and, in this sense, biofilm-forming MDR-methicillin …

[HTML][HTML] Ceftriaxone and melittin synergistically promote wound healing in diabetic rats

NA Alhakamy, G Caruso, BG Eid, UA Fahmy… - Pharmaceutics, 2021 - mdpi.com
High glucose levels in diabetic patients are implicated in delay wound healing that could
lead to more serious clinical complications. The aim of the present work was to examine the …

Chicken feather hydrochar incorporated with phenolic extract of Rosa damascena Mill. to enlarge the antibacterial performance against Acinobacter baumannii and …

EAE Eliuz, E Yabalak - Journal of Environmental Chemical Engineering, 2022 - Elsevier
In this study, an aqueous extract of Rosa damascene (RAE) was incorporated into chicken
feather hydrochar (CFH) to enhance the antibacterial activity of the extract on Acinobacter …

Functional and expression characteristics identification of Phormicins, novel AMPs from Musca domestica with anti-MRSA biofilm activity, in response to different …

B Wang, PW Wei, Y Yao, CR Song, X Wang… - International Journal of …, 2022 - Elsevier
Antibiotic-resistant bacteria (including MRSA) in the clinic pose a growing threat to public
health, and antimicrobial peptides (AMPs) have great potential as efficient treatment …

Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades

MA dos Santos Ramos, LG de Toledo, L Sposito… - International Journal of …, 2021 - Elsevier
The rate of infections caused by resistant bacteria to the antimicrobials available for human
use grows exponentially every year, which generates major impacts on human health and …