Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
[HTML][HTML] Regulation and function of the mammalian tricarboxylic acid cycle
PK Arnold, LWS Finley - Journal of Biological Chemistry, 2023 - ASBMB
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …
metabolic pathway that performs the essential function of oxidizing nutrients to support …
Brown adipose tissue—a translational perspective
AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
[HTML][HTML] Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver
X Fu, JA Fletcher, S Deja… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated,
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …
Antioxidant and anti-aging activities of Laminaria japonica polysaccharide in Caenorhabditis elegans based on metabonomic analysis
N Li, Q Li, X He, X Gao, L Wu, M Xiao, W Cai… - International journal of …, 2022 - Elsevier
In this study, Laminaria japonica polysaccharide (LJP) was measured in vitro against three
antioxidant indicators: DPPH, ABTS, and hydroxyl. In vivo, LJP investigated thermal …
antioxidant indicators: DPPH, ABTS, and hydroxyl. In vivo, LJP investigated thermal …
[HTML][HTML] Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-
CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation …
CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation …
[HTML][HTML] Thermodynamic principle to enhance enzymatic activity using the substrate affinity
Understanding how to tune enzymatic activity is important not only for biotechnological
applications, but also to elucidate the basic principles guiding the design and optimization of …
applications, but also to elucidate the basic principles guiding the design and optimization of …
INCA 2.0: A tool for integrated, dynamic modeling of NMR-and MS-based isotopomer measurements and rigorous metabolic flux analysis
Metabolic flux analysis (MFA) combines experimental measurements and computational
modeling to determine biochemical reaction rates in live biological systems. Advancements …
modeling to determine biochemical reaction rates in live biological systems. Advancements …
[HTML][HTML] Redox stress shortens lifespan through suppression of respiratory complex I in flies with mitonuclear incompatibilities
Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism
Oxygen deprivation can be detrimental. However, chronic hypoxia is also associated with
decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude …
decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude …