Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated,
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …

In this study, Laminaria japonica polysaccharide (LJP) was measured in vitro against three
antioxidant indicators: DPPH, ABTS, and hydroxyl. In vivo, LJP investigated thermal …

Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-
CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation …

Understanding how to tune enzymatic activity is important not only for biotechnological
applications, but also to elucidate the basic principles guiding the design and optimization of …

Metabolic flux analysis (MFA) combines experimental measurements and computational
modeling to determine biochemical reaction rates in live biological systems. Advancements …

Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …

Oxygen deprivation can be detrimental. However, chronic hypoxia is also associated with
decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude …